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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. Molecular Weight: 1187.3. KTSAVLQ-Rhodamine110-y-Glu (Lys-Tyr-SerAla-Val-Leu-Glu-Rh110-y-Glu) is a Rhodamine110 labeled fluorogenic peptidyl substrate that can be hydrolyzed by 3CLpro (Mpro) (#SBB-DE0129) a chemotrypsin-like protease, cleaving between the glutamine and the Rhodamine110 fluorophore. Prior hydrolysis, the Rhodamine110 moiety is quenched resulting in a very low background. This substrate is ideal for activity determination of 3CLpro and suitable for HTS or pilot screens in search for potential inhibitors due to its red-shifted fluorescence compared to AMC or Dabcyl/Edans substrates. This results in less interference with potential inhibitors in screeing campaigns. Ex/Em=485nm/535nm (recommended).
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