LAG-3 (mouse):Fc (mouse) (rec.)

Product description: Protein. The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3). Source: CHO cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Liquid. In PBS. Binds to human and mouse MHC class II. Purity: >95% (SDS-PAGE). Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

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