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100 mg

Ref. SYN-1213-M100
SynKinase
1211441-98-3

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Neuf 658.00 H.T.

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Détails Produit

Product description: Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Alternate Names/Synonyms: LEE-011; Ribociclib

Product Type: Chemical

Molecular Formula: C23H30N8O

Molecular Weight: 434.5

CAS: 1211441-98-3

Purity: >95%

InChiKey: RHXHGRAEPCAFML-UHFFFAOYSA-N

Appearance Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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