Maclura pomifera Lectin (MPL/MPA) - Pure

Product Description
Maclura pomifera agglutinin/lectin (MPA/MPL) is tetrameric plant seed isolated from osage orange, Maclura pomifera, and has a high affinity for tumor-associated T-antigen disaccharide (GalBeta1,3GalNAcα) and many O-linked glycopeptide structures. Interactions with GalNAc predominate in binding of the disaccharide. The structure of GalBeta1,3GalNAcα occurs on the surface of tumor cells as a mucin-associated antigenic marker, termed as T-antigen. It is also the central element in O-linked glycopeptide structures on other mammalian glycoproteins.

Maclura pomifera agglutinin has a molecular weight of about 44,000 Da and consists of four subunits. This lectin has isoelectric points of pH 4.8 to 5.3 and blood group specificity towards A, B, and O (-SA).

This product comes in a lyophilized powder form and is stored at -20 C. Reconstitute with sterile buffer. No metal ions are required for binding.

Applications:
Suitable for use in ELISA

References

• Lee, X., et al. Structure of the complex of Maclura pomifera agglutinin and the T-antigen disaccharide, GalBeta1,3GalNAc. J Biol Chem. (1998) 273:6312-6318.