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1 mg

Ref. SYN-1054-M001
SYNKINASE
457081-03-7

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Neuf 233.00 H.T.

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Détails Produit

Product description: Chemical. CAS: 457081-03-7. Formula: C18H16FN3O. MW: 309.3. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5. In research comparing Merck 5 (Pyridone 6) to the Jak inhibitor AG490, Merck 5 demonstrated much lower effective drug concentrations and faster kinetics and appear to be a more sensitive and specific inhibitor of JAK-STAT3 activity compared with AG490 and potently inhibited the growth of primary myeloma cells and myeloma-derived cell lines grown on bone marrow-derived stromal cells .

Alternate Names/Synonyms: Pyridone 6

Product Type: Chemical

Molecular Formula: C18H16FN3O

Molecular Weight: 309.3

CAS: 457081-03-7

Purity: >95%

InChiKey: VNDWQCSOSCCWIP-UHFFFAOYSA-N

Appearance: Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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