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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)
50 µg
photos non contractuelles
Détails Produit
Product description: Recombinant Protein. Mpro (Papain-like Protease) (aa 1540-1841) is fused at the N-terminus to a His-tag.. Source: E. coli. Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 1mM TCEP. 3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of alpha-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli.
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