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50 µg

Ref. SBB-PS0003-C050
SOUTH BAY BIO

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Neuf 302.00 H.T.

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Détails Produit

Product Description: NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8) is a ubiquitin like protein that plays an important role in regulating development and the cell cycle. NEDD8 is conjugated to a target protein via a signaling cascade similar to ubiquitin: a NEDD8 specific E1 activating enzyme (APPBP1/UBA3) adenylates the C-terminus of NEDD8 which is than subsequently passed to an E2 conjugating enzyme (UBE2M or UBE2F) that facilitates covalent attachment of NEDD8 to a cullin subunit of an SCF E3 ubiquitin ligase. NEDD8-Rhodamine 110 can be used as a substrate for enzymes exhibiting deNEDDylating activity, e.g UCH-L3, UCH-L1, COP9 Signalosome and NEDP1.

Alternate Names/Synonyms: Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8; Neddylin; Rub1

Product type: Protein

Source / Host: E. coli

Sequence: Human NEDD8 (aa1-76) conjugated at the C-terminus to a quenched Rhodamine 110 dye.

Species Crossreactivity: Human

Molecular Weight: ~9kDa

Labels - Conjugates: Rhodamine

Purity: >97% (LCMS)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM MES pH 6.0, 150mM sodium chloride.

Handling Advice: Aliquot to avoid freeze/thaw cycles. Protect from light.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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