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50 µg

Ref. SBB-DE0025-C050
SOUTH BAY BIO

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Neuf 147.00 H.T.

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Détails Produit

Product Description: NEDP1 is a deconjugating enzyme with specificity towards NEDDylated substrates. NEDP1 discriminates between ubiquitinated and NEDDylated targets, despite similar C-terminal regions. NEDP1 is a protease which hydrolyzes the isopeptide bond between the C-terminus of NEDD8 and the respective lysine of the substrate protein to which the NEDD8 is covalently bound. NEDP1 is important in regulating cullin associated ubiquitin ligase enzymes such as those of the SCF (Skp-Cullin-Fbox) family and subsequently, it is important in regulating cell cycle progression and other biological functions.

Alternate Names/Synonyms: NEDD8-specific Protease 1; Sentrin-specific Protease 8; Deneddylase-1; Sentrin/SUMO-specific Protease SENP8; DEN1; PRSC2

Product type: Protein

Source / Host: E. coli

Sequence: Human NEDP1 (aa2-212) is fused at the N-terminus to a His-tag.

Species Crossreactivity: Human

Molecular Weight: ~27kDa

TAGs: His

Purity: >95% (SDS-PAGE)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.

Handling Advice: Aliquot to avoid freeze/thaw cycles.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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