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5 mg

Ref. SYN-1141-M005
SynKinase
257933-82-7

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Neuf 144.00 H.T.

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Détails Produit

Product description: Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.

Alternate Names/Synonyms: EKB-569

Product Type: Chemical

Molecular Formula: C24H23ClFN5O2

Molecular Weight: 467.9

CAS: 257933-82-7

Purity: >95%

InChiKey: WVUNYSQLFKLYNI-AATRIKPKSA-N

Appearance Solid.

Solubility: Soluble in DMSO or ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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