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50 mg

Ref. SYN-1064-M050
SYNKINASE
717907-75-0

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Neuf 778.00 H.T.

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Détails Produit

Product description: Chemical. CAS: 717907-75-0. Formula: C21H20F3N7O3S. MW: 507.5. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.

Alternate Names/Synonyms: PF562271

Product Type: Chemical

Molecular Formula: C21H20F3N7O3S

Molecular Weight: 507.5

CAS: 717907-75-0

Purity: >95%

InChiKey: MZDKLVOWGIOKTN-UHFFFAOYSA-N

Appearance: Solid.

Solubility: Soluble in DMSO or ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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