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50 µg

Ref. SBB-DE0024-C050
SOUTH BAY BIO

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Neuf 197.00 H.T.
en stock

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Détails Produit

Product Description: The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63 linked polyubiquitin chains (free chains or from cellular substrates). It works in concert together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It strongly antagonizes the innate immune induction of type I interferon by blocking the phosphorylation, dimerization and therefore the nuclear translocation of host IRF3. In addition, it prevents also host NF-kappa-B signaling.

Alternate Names/Synonyms: Papain-like Proteinase; SARS Coronavirus Main Proteinase; Non-structural Protein 3; PL2-PRO; Nsp3

Product type: Protein

Source / Host: E. coli

Sequence: PLpro (Papain-like Protease) (aa 1540-1841) is fused at the N-terminus to a His-tag.

Species Crossreactivity: Human

Molecular Weight: ~37kDa

TAGs: His

Purity: >95% (SDS-PAGE)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.

Handling Advice: Aliquot to avoid freeze/thaw cycles.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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