Progranulin (human) ELISA Kit

Product description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimer‘s disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Alternate Names/Synonyms: Proepithelin; PEPI; PC Cell-derived Growth Factor

Product Type: Kit

Specificity: Detects human progranulin.

Crossreactivity: Human

Sensitivity: 32pg/ml

Range: 0.063 to 4ng/ml

Sample Type: Cell Culture Supernatant, Plasma, Serum, Urine

Assay Type: Sandwich

Detection Type: Colorimetric

Other data: NOTE: The TwinPlex size is supplied as 2 independent SinglePlate Kits from the same lot.

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.

Handling Advice After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.

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