Pseurotin A

Product description: Antibiotic. Chitin synthase, monoamine oxidase and IgE production inhibitor. Cytotoxic. Shows nematicidal and antileishmanial activity. Antiproliferative against four different glioma cells. Downregulates the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulates the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C, important regulators for tricarboxylic acid cycle and oxidative phosphorylation.

Alternate Names/Synonyms: (5S,8S,9R)-8-Benzoyl-2-((1S,2S,Z)-1,2-dihydroxyhex-3-en-1-yl)-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione

Product Type: Chemical

Molecular Formula: C22H25NO8

Molecular Weight: 431.4

CAS: 58523-30-1

Source / Host: Isolated from Aspergillus fumigatus.

Purity: >98% (HPLC)

InChiKey: SLYDIPAXCVVRNY-UOWMTANKSA-N

Appearance White to off-white powder.

Solubility: Soluble in methanol or ethyl acetate; poorly soluble in water.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.

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