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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 537-42-8. Formula: C16H16O3. MW: 256.3. Synthetic. Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 µM for pterostilbene, 3.2 µM for resveratrol), and inhibits cell proliferation (IC50 = ~60 µM for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-kappaB and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).
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