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2 mg

Ref. AG-CR1-3653-M002

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Neuf 120.00 H.T.


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Détails Produit

Product description: Chemical. CAS: 1680206-61-4. Formula: C20H32O4. MW: 336.5. Synthetic. Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.

Alternate Names/Synonyms: 3-Dodecyl-4,5-dimethoxy-3,5-cyclohexadiene-1,2-dione; 5-LO Inhibitor RF-22c

Product Type: Chemical

Molecular Formula: C20H32O4

Molecular Weight: 336.5

CAS: 1680206-61-4

Source / Host: Synthetic.

Purity: >98% (HPLC)


Appearance: Orange solid.

Solubility: Soluble in DMSO (1mg/ml), ethanol or chloroform. Insoluble in water.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

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