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5 mg

Ref. SYN-1189-M005
SynKinase
1184843-57-9

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Neuf 461.00 H.T.

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Détails Produit

Product description: SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.

Alternate Names/Synonyms: SAR020106

Product Type: Chemical

Molecular Formula: C19H19ClN6O

Molecular Weight: 382.9

CAS: 1184843-57-9

Purity: >95%

InChiKey: SRBJWIBAMIKCMV-GFCCVEGCSA-N

Appearance Solid.

Solubility: Soluble in DMSO.

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: AMBIENT

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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