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1 mg

Ref. SYN-1076-M001
SynKinase
193746-75-7

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Neuf 266.00 H.T.

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Détails Produit

Product description: Chemical. CAS: 193746-75-7. Formula: C19H20FN5O. MW: 353.4. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. SB-242235 exhibits good oral availability in preclinical studies and has micromolar or submicomolar in vivo IC(50) values. However it is clear from studies examining SB-242235 effects on metabolism, for instance in chondrocytes and human cartilage that SB-242235 effects can be pleiotropic between species and that care must be taken when studying the interactions of multi-target inhibitors such as SB-242235.

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