AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product Description: SUMO/Sentrin Specific Peptidase 1 (SENP1) is a member of the SENP family of proteases, which belong to the group of cysteine-type peptidases. SENP1 is a SUMO-specific enzyme that catalyzes two essential functions. Processing the full-length versions of SUMO1, SUMO2 and SUMO3 into its mature forms and the deconjugation of SUMOylated proteins. SENP1 is expressed in many organs and is localized in the nucleus as well as the cytoplasm. SENP1 is thought to play a role in the development, progression and metastasis of prostate cancer and has been shown to regulate erythropoietin production during hypoxia by regulating the stability of HIF1-alpha. Furthermore, SENP1 deconjugates SUMO1 from HIPK2, HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. SENP1 has been shown to desumoylate CCAR2, which subsequently decreases the interaction with SIRT1.
Alternate Names/Synonyms: Sentrin-specific Protease 1; Sentrin/SUMO-specific Protease SENP1
Product type: Protein
Source / Host: E. coli
Sequence: Human SENP1 (catalytic domain aa 387-644) fused at the N-terminus to a His-tag.
Species Crossreactivity: Human
Molecular Weight: ~32kDa
Purity: >95% (SDS-PAGE)
Concentration: Lot dependent.
Formulation: Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 10% glycerol, 1mM TCEP.
Handling Advice: Aliquot to avoid freeze/thaw cycles.
Short Term Storage: -80°C
Long Term Storage: -80°C
Shipping: DRY ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.
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