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50 ug

Ref. AG-40A-0059-C050
AdipoGen Life Sciences

photos non contractuelles

Neuf 420.00 H.T.


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Détails Produit

Product Description: The ST2 (Interleukin-1 receptor-like 1; Interleukin-33 receptor) gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signaling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.

Alternate Names/Synonyms: Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; IL-33 Receptor; Interleukin-33 Receptor

Product type: Protein

Source / Host: HEK 293 cells

Sequence: Signal peptide and the sequence of isoform 2 of human ST2 (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1.

Species Crossreactivity: Human

Specificity: Binds to human IL-33.

SBiological Activity: Activates ERK phosphorylation in THP-1 cells.

Molecular Weight: ~90kDa (SDS-PAGE)

TAGs: Fc

Purity: >90% (SDS-PAGE)

Endotoxin: <0.1EU/µg purified protein (LAL test; Lonza).

Concentration: ~0.5mg/ml

Formulation: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.

Handling Advice: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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