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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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trans-Indole-3-acrylic acid
1 g
photos non contractuelles
Détails Produit
Product description: Inflammation suppressor. Tryptophan metabolite produced by human microbiota (intestinal commensale Peptostreptococcus sp.). Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory Bowel Disease (IBD) have an altered microbiota, with less Peptostreptococcus sp. and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthase. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase (TDO), indoleamine-2,3-dioxygenase (IDO), L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers. Used as heterocyclic building block or intermediate for the synthesis of indolyl acrylamide-derived inhibitors, pharmaceuticals or agrochemicals.
Alternate Names/Synonyms: IAcrA; trans-3-Indoleacrylic acid; trans-beta-Indoleacrylic acid; (E)-3-(1H-Indol-3-yl)acrylic acid; NSC29428; NSC137806; BRN0006317
CAS: 29953-71-7
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