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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 58880-19-6. Formula: C17H22N2O3. MW: 302.4. Synthetic. Originally isolated from Streptomyces hygroscopicus.. Antibiotic, antifungal and antiprotozoal agent. Potent and reversible, cell permeable inhibitor of class I and II histone deacetylases (HDACs). Anticancer, immunosuppressive, antifibrogenic compound. Induces apoptosis and cell growth arrest at both G1 and G2/M phases. Also inactivates mitotic spindle checkpoint. Enhances the efficacy of anticancer agents that target DNA. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Telomerase inhibitor. Smooth muscle cell proliferation inhibitor. Anti-inflammatory and inhibits osteoclastogenesis and bone resorption. Promotes either self-renewal or differentiation of embryonic stem cells.
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