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100 µg

Ref. SBB-CE0019-C100
SOUTH BAY BIO

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Neuf 236.00 H.T.

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Détails Produit

Product Description: UBE2D3 (UbcH5c) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D3 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D3-Ub thioester. UBE2D3 is capable of associating with numerous known E3 ligases including MDM2, which target proteins such as p53 for proteasomal degradation through polyubiquitination.

Alternate Names/Synonyms: Ubiquitin-conjugating Enzyme H5c; PUBC; UBC5C; Ubiquitin-protein Ligase D3; p53-regulated Ubiquitin-conjugating Enzyme

Product type: Protein

Source / Host: E. coli

Sequence: Human UBE2D3 (aa1-147) is untagged.

Species Crossreactivity: Human

Molecular Weight: ~17kDa

TAGs: no Tag

Purity: >95% (SDS-PAGE)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM HEPES pH 8, 200mM sodium chloride, 10% glycerol (v/v), 1mM TCEP.

Handling Advice: Aliquot to avoid freeze/thaw cycles.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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