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50 µg

Ref. SBB-CE0058-C050
SOUTH BAY BIO

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Neuf 170.00 H.T.

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Détails Produit

Product Description: UBA1, the canonical ubiquitin E1 activating enzyme is a 118kDa protein, which forms a homodimer in its active state and catalyzes the first step of the ubiquitin conjugation cascade. It activates ubiquitin in an ATP-dependent mechanism where ATP is hydrolyzed to AMP and PPi, a ubiquitin C-terminal adenylate intermediate is formed, then transferred to the E1's active site cysteine through a thioester bond. This thioester is then transferable to an E2 conjugating enzyme's active site cysteine.

Alternate Names/Synonyms: Ubiquitin E1 Enzyme; Ubiquitin-like Modifier-activating Enzyme 1; A1S9T; AMCX1; GXP1; POC20; SMAX2

Product type: Protein

Source / Host: Sf21 cells

Sequence: Human UBA1 (aa12-1058) is fused at the N-terminus to a His-tag.

Species Crossreactivity: Human

Molecular Weight: ~120kDa

TAGs: His

Purity: >95% (SDS-PAGE)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM HEPES pH 7.5, 150mM sodium chloride, 10% glycerol, 2mM TCEP.

Handling Advice: Aliquot to avoid freeze/thaw cycles.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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