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Product Description: Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity and promote or prevent protein interactions. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various linkage specificities. This product consists of a full-length human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a C-terminal warhead (Vinyl Methyl Ester). Ubiquitin vinyl methyl ester is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl methyl ester group. Ubiquitin vinyl methyl ester can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets three of the four major DUB families: UCH (Ubiquitin C-terminal hydrolases), USP (Ubiquitin specific proteases), OTU (Ovarian tumor proteases) and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited.
Product type: Protein
Source / Host: E. coli
Sequence: Human ubiquitin (aa1-76) with a C-terminal vinyl methyl ester group.
Species Crossreactivity: Human
Molecular Weight: ~9kDa
Purity: >97% (LCMS)
Concentration: Lot dependent.
Formulation: Liquid. In 50mM MES pH 6.0, 100mM sodium chloride.
Handling Advice: Aliquot to avoid freeze/thaw cycles.
Short Term Storage: -20°C
Long Term Storage: -80°C
Shipping: DRY ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.
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