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5 mg

Ref. AG-CR1-3704-M005
ADIPOGEN LIFE SCIENCES
1258513-40-4

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Neuf 160.00 H.T.
en stock

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Détails Produit

  • Most water soluble synthetic monocarbonyl analog of curcumin (MAC) for in vitro and in vivo application.
  • Potently inhibits NF-κB and its nuclear translocation by suppressing IKK-α and IKK-β, consequently leading to apoptosis.
  • Potent DNA hypomethylating agent. Inhibits HSP90 and NF-κB leading to downregulation of DNA methyltransferase-1 (DNMT-1) expression.
  • Cytotoxic against several cancers in vitro and in vivo. Shows excellent activity against xenografts of head and neck squamous cell carcinoma, pancreatic cancer, colon cancer and breast cancer.
  • Antiangiogenic agent. Induces the downregulation of HIF-1α, HSP90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.
  • Shows preventive effects on bone loss induced by breast cancer cell bone metastasis.  Found to have a potential stimulating effect on osteoblastogenesis and a suppressive effect on osteoclastogenesis in vitro through Smad activation and NF-κB inhibition. May have promise in the development into an antiosteoporotic agent capable of promoting new bone formation while simultaneously reducing bone resorption.
Product Details
Synonyms (3E,5E)-1-Methyl-3,5-bis(2-pyridinylmethylene)-4-piperidinone; Monocarbonyl Analog of Curcumin
Product Type Chemical
Properties
Formula

C18H17N3O

MW 291.4
CAS 1258513-40-4
Purity Chemicals ≥95% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
Other Product Data

Note: Always prepare and use fresh solution. We recommend to use the fresh solution within the same day. The product can degrade in solution over time. 

InChi Key VCLPNFMJSSBBKX-WFYKWJGLSA-N
Smiles O=C(/C(CN(C)C/1)=C/C2=NC=CC=C2)C1=C\C3=CC=CC=N3
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF