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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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VISTA [B7-H5] (human) (rec.) (His)
3 x 10 µg
photos non contractuelles
Détails Produit
Product description: Protein. The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin: <0.01EU/µg. Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
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