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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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VX-745
50 mg
photos non contractuelles
Détails Produit
Product description: Chemical. CAS: 209410-46-8. Formula: C19H9Cl2F2N3OS. MW: 436.3. VX-745 is a potent inhibitor of p38? MAPK (IC50=10nM) with 20-fold selectivity over p38? and 1000-fold selectivity over closely related kinases, ERK1, MK2 and JNK1-3. p38? is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases and is widely expressed in endothelial, immune or inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-?, IL-1? and IL-6. VX-745 is an anti-inflammatory agent that blocks IL-1? and TNF-? release in whole blood in vitro with IC50 values of 150 and 180nM, respectively. VX-745 showed anti-inflammatory efficacy in an animal model of rheumatoid arthritis and recently anti-neuroinflammatory potential in prevention of early-stage Alzheimers diseases (AD).
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