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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Chemical. CAS: 129830-38-2 | 146986-50-7 (free base). Formula: C14H21N3O . 2HCl. MW: 247.3 . 72.9. Synthetic. Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor [1,3-5]. Tumor cell invasion and metastasis suppressor [2, 15]. Smooth muscle relaxant [1, 6]. Decreases liver fibrosis by hepatic stellate cell growth inhibition [7, 8]. Antinociceptive [9]. Blocks generation of inflammatory cytokines [10]. Stem cell research modulator [11-14, 16]. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their pluripotency. Increases survival rate of hES cells undergoing cryopreservation [11-14, 16].
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