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1 mg

Ref. SYN-1100-M001
SYNKINASE
439081-18-2

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Neuf 96.00 H.T.

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Détails Produit

Product description: Chemical. CAS: 439081-18-2. Formula: C24H25ClFN5O3. MW: 486. Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.

Alternate Names/Synonyms: Tovok; BIBW-2992

Product Type: Chemical

Molecular Formula: C24H25ClFN5O3

Molecular Weight: 486

CAS: 439081-18-2

Purity: >95%

InChiKey: ULXXDDBFHOBEHA-CWDCEQMOSA-N

Appearance: Solid.

Solubility: Soluble in DMSO or ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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