anti-MPC-2, mAb (JCM-1)

Product description: Monoclonal Antibody. Recognizes endogenous human and mouse MPC-2. Isotype: Mouse IgG2bkappa. Clone: JCM-1. Applications: IP, WB. Liquid. In PBS containing 25% glycerol and 0.02% sodium azide. Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Two proteins, mitochondrial pyruvate carriers MPC-1 and MPC-2, form a heterooligomeric complex in the IMM to facilitate pyruvate transport. This step is required for mitochondrial pyruvate oxidation and carboxylation-critical reactions in intermediary metabolism that are dysregulated in several common metabolic diseases.

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