anti-MPC-2, mAb (JCM-1)

Product description: Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Two proteins, mitochondrial pyruvate carriers MPC-1 and MPC-2, form a heterooligomeric complex in the IMM to facilitate pyruvate transport. This step is required for mitochondrial pyruvate oxidation and carboxylation-critical reactions in intermediary metabolism that are dysregulated in several common metabolic diseases.

Alternate Names/Synonyms: Mitochondrial Pyruvate Carrier 2; Brain Protein 44

Product Type: Monoclonal Antibody

Clone: JCM-1

Isotype: Mouse IgG2bkappa

Immunogen: Peptide coupled to KLH.

Applications: IP, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes endogenous human and mouse MPC-2.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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