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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, vesicles, cells, tissue and even small whole animals over several days without side effects [2,4,5,7-9]. Stronger fluorescent intensity under acidic conditions and barely detectable in alkaline solutions (wide range from pH 4 to pH 8) [2]. Highly cell/membrane permeable. Trapped within the cells and acidic organelles through hydrophobic interactions with the inner side of the membranes [2]. Barely metabolized and long-term stable, thus slow photobleaching [9]. Angiogenesis inhibitor [1,3,6]. Inhibitor of matrix metalloproteinases MMP-1,-2,-8,-9,-12,-13 [1, 3-6]. TYK2, DYRK2,Dyrk1A, YSK4 and RPS6KA1/2 inhibitor [3,5,6].
Alternate Names/Synonyms: (4-(4,5-Dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]-pyridin-2-amine) . TFA
CAS: 950766-21-9 | 643020-13-7 (free base)
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