anti-5-Formylcytosines (5-fC), Rabbit Monoclonal (RM477)

Product description: 5-Formylcytosine (5fC) is a pyrimidine nitrogen base derived from cytosine and a recently discovered modification of DNA. Just as 5-hydroxymethylcytosine (5-hmC) is generated when the Tet family of cytosine oxygenase enzymes converts 5-methylcytosine (5-mC), it has been shown that continued activity of the Tet proteins on hydroxymethylcytosine will generate 5-formylcytosine (5-fC) and 5-carboxylcytosine. It is believed that this conversion process may represent a pathway of DNA demethylation.

Alternate Names/Synonyms: 5-fC

Product Type: Recombinant Antibody

Clone: RM477

Isotype: Rabbit IgG

Immunogen: KLH-conjugated 5-Formylcytosine.

Applications: ELISA, DotBlot

Species Crossreactivity: All

Specificity: RM477 reacts to 5-Formylcytosine (5-fC) in DNA. No cross-reactivity with non-modified cytosine and other modified cytosines in DNA.

Concentration: 1 mg/ml

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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