anti-ACE2 (human), mAb (AC18F) (ATTO 488)

Product description: Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

Alternate Names/Synonyms: SARS Receptor; Angiotensin-converting Enzyme 2; ACEH; Metalloprotease MPROT15; SARS-CoV-2 Receptor

Product Type: Monoclonal Antibody

Clone: AC18F

Isotype: Mouse IgG1kappa

Immunogen: Recombinant human ACE2.

Labels - Conjugates: ATTO 488

Applications: FACS

Species Crossreactivity: Human

Specificity: Recognizes human ACE2. Does not detect recombinant human ACE2 that has a tag at the C-terminus of the protein.

Endotoxin: <0.01EU/µg purified protein (LAL-test; Lonza)

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability: Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.

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