anti-Acetyl-CoA Carboxylase (human), Rabbit Monoclonal (RM232)

Product description: Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). The function of ACC is to regulate the metabolism of fatty acids. When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria. There are two ACC forms, alpha (ACC1) and beta (ACC2), encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.

Alternate Names/Synonyms: ACC1; Acetyl-Coenzyme A Carboxylase alpha

Product Type: Recombinant Antibody

Clone: RM232

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to human Acetyl CoA Carboxylase 1.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human Acetyl CoA Carboxylase 1. This antibody may also react to mouse or rat Acetyl CoA Carboxylase 1, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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