anti-AIM2 (human), mAb (3B10)

Product description: AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

Alternate Names/Synonyms: Interferon-inducible Protein AIM2; Absent in Melanoma 2

Product Type: Monoclonal Antibody

Clone: 3B10

Isotype: Mouse IgG1

Immunogen: Human AIM2 (aa 1-186).

Applications: ICC, WB

Species Crossreactivity: Human

Specificity: Recognizes human AIM2.

Endotoxin: <0.1EU/µg purified protein (LAL test; Lonza).

Concentration: 1 mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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