anti-alpha-synuclein (SYUA), Rabbit Monoclonal (RM492)

Product description: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Alternate Names/Synonyms: SYUA

Product Type: Recombinant Antibody

Clone: RM492

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the C-terminus of human alpha-Synuclein.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse, Rat

Specificity: RM492 reacts to human, mouse or rat alpha-Synuclein (SYUA).

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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