anti-Aurora-B (human), Rabbit Monoclonal (RM278)

Product description: Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.

Alternate Names/Synonyms: AURKB

Product Type: Recombinant Antibody

Clone: RM278

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus of human Aurora kinase B.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human Aurora kinase B.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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