anti-BAG-1 (human), Rabbit Monoclonal (RM356)

Product description: BAG-1 belongs to a family of evolutionary conserved proteins, containing an approximately 110 amino acid sequence termed the BAG domain that defines the protein family. BAG1 was identified in a screen of interacting proteins of the anti-apoptotic protein BCL2. BAG1 shares no significant homology with BCL2 or other BCL2 family proteins, which can form homo- and heterodimers. However, coexpression of BAG1 and BCL2 provided markedly increased protection from cell death induced by several stimuli. BAG1 itself is made up of different isoforms translated from a single mRNA by alternative translational initiation, resulting in similar carboxy-terminal sequences but different N-terminal sequences. In humans, there are four BAG1 isoforms (BAG1L, 1M, 1 and 1S). The multiple protein isoforms interact with diverse partners, including chaperones Hsc70/Hsp70, Ser/Thr kinase Raf-1 and Bcl-2, to promote cancer cell survival. The BAG-1L isoform specifically binds to and increases the transcriptional activity of oestrogen receptor in cells, and in some, but not all studies, BAG-1 expression is predictive of clinical outcome in breast cancer.

Alternate Names/Synonyms: Bcl-2-associated Athanogene 1; BAG Family Molecular Chaperone Regulator 1

Product Type: Recombinant Antibody

Clone: RM356

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to human BAG-1 (Bcl-2-associated athanogene 1).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to total human BAG-1 protein, including long (BAG-1L), medium (BAG-1M) and short (BAG-1S) isoforms.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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