anti-BimS/EL/L, mAb (3C5)

Product description: Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.

Alternate Names/Synonyms: BCL2L11; Bcl-2-like Protein 11; Bcl2-interacting Mediator of Cell Death

Product Type: Monoclonal Antibody

Clone: 3C5

Isotype: Rat IgG2akappa

Immunogen: Synthetic peptide corresponding to aa 20-40 of mouse BimL.

Applications: ELISA, FACS, ICC, IHC, IP, WB

Species Crossreactivity: Dog, Human, Monkey, Mouse, Rat

Specificity: Recognizes an epitope within aa 20-40 of human, mouse, rat, monkey and dog BimL (~19kDa), BimEL (~23kDa), and BimS (~16kDa). Also recognizes the six novel isoforms of human Bim, generated by alternative splicing and lacking the C-terminal hydrophobic region.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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