anti-CALD1 (human), Rabbit Monoclonal (RM396)

Product description: CALD1 (Caldesmon) is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This calmodulin- and actin-binding protein plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin and phospholipids. It is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

Alternate Names/Synonyms: Caldesmon

Product Type: Recombinant Antibody

Clone: RM396

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to Human CALD1 .

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human CALD1 .

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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