anti-Calponin-1, Rabbit Monoclonal (RM262)

Product description: Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.

Alternate Names/Synonyms: Calponin H1, Smooth Muscle

Product Type: Recombinant Antibody

Clone: RM262

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human Calponin-1.

Applications: ICC, WB

Species Crossreactivity: Human, Mouse

Specificity: This antibody reacts to human or mouse Calponin-1.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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