anti-CD140b (C-term) (human), Rabbit Monoclonal (RM303)

Product description: CD140b (PDGFRbeta) is a typical receptor tyrosine kinase, which belongs to the type III tyrosine kinase receptor (RTK) family and is structurally characterized by five extracellular immunoglobulin-like domains, a single membrane-spanning helix domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain and a carboxylic tail. CD140b is a cell surface receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor (also termed macrophage-colony stimulating factor receptor), all three of which may be lost together by a single deletional mutation thereby causing development of the 5q-syndrome. Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in and chromosome translocations causing fusions between PDGFRB and any one of at least 30 genes can cause Myeloproliferative neoplasms that commonly involve eosinophilia, eosinophil-induced organ injury, and possible progression to aggressive leukemia

Alternate Names/Synonyms: PDGFR-beta; Platelet-derived Growth Factor Receptor beta

Product Type: Recombinant Antibody

Clone: RM303

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human CD140b.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human CD140b (PDGFR-beta) (Platelet-derived growth factor receptor beta).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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