anti-CD23 (human), Rabbit Monoclonal (RM406)

Product description: CD23 (Fc epsilon RII; FcepsilonRII) is a glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is a low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, found on B cells. It is expressed on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. Functionally, CD23 is involved in B cell growth and differentiation and IgE production. CD23 is known to have a role of transportation in antibody feedback regulation. CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

Alternate Names/Synonyms: Low Affinity Immunoglobulin epsilon Fc Receptor; BLAST-2; C-type Lectin Domain Family 4 Member J; Fc-epsilon-RII; Immunoglobulin E-binding Factor; Lymphocyte IgE Receptor

Product Type: Recombinant Antibody

Clone: RM406

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the C-terminus of human CD23.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human to CD23.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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