anti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (Biotin)

Product description: CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.

Alternate Names/Synonyms: B7-H1; Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1

Product Type: Monoclonal Antibody

Clone: ANC6H1

Isotype: Mouse IgG1kappa

Immunogen: Recombinant human CD274(B7-H1).

Labels - Conjugates: Biotin

Applications: ELISA, FACS

Species Crossreactivity: Human

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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