anti-CD278 (human), Rabbit Monoclonal (RM417)

Product description: CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.

Alternate Names/Synonyms: ICOS; Inducible T-cell Costimulator; Activation-inducible Lymphocyte Immunomediatory Molecule

Product Type: Recombinant Antibody

Clone: RM417

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human CD278.

Applications: IHC

Species Crossreactivity: Human

Specificity: This antibody reacts to human CD278.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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