anti-CD28 (human), Rabbit Monoclonal (RM404)

Product description: CD28 is a homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.

Alternate Names/Synonyms: T-cell-specific Surface Glycoprotein CD28; TP44

Product Type: Recombinant Antibody

Clone: RM404

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the C-terminus of human CD28.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human to CD28.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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