anti-CD31 (human), Rabbit Monoclonal (RM247)

Product description: CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. As a biomarker CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumor angiogenesis, which can imply a rapidly growing tumor.

Alternate Names/Synonyms: PECAM-1; Platelet Endothelial Cell Adhesion Molecule

Product Type: Recombinant Antibody

Clone: RM247

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the cytoplasmic domain of human CD31.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human CD31 (Platelet endothelial cell adhesion molecule, PECAM-1).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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