anti-CD33 (human), Rabbit Monoclonal (RM398)

Product description: CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also a useful marker for peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

Alternate Names/Synonyms: Myeloid Cell Surface Antigen CD33; Sialic Acid-binding Ig-like Lectin 3; Siglec-3; gp67

Product Type: Recombinant Antibody

Clone: RM398

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to Human CD33.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human CD33.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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