anti-CD3E (human), Rabbit Monoclonal (RM344)

Product description: The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum, but it is not expressed on B or NK cells. T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2.

Alternate Names/Synonyms: T-cell Surface Glycoprotein CD3 epsilon Chain

Product Type: Recombinant Antibody

Clone: RM344

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human CD3 epsilon chain.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to the cytoplasmic domain of human CD3 epsilon chain.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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